Schools have direct contact with over 50 million students for at least 6 hours a day over 13 key years of their social, physical, and intellectual development. Schools can identify and prevent adolescent behaviors that put them at risk for HIV, STD and teen pregnancy. School curricula, policies, and services are generally locally determined by local education agencies (LEA), or local school districts, with guidance from the state education agency (SEA). LEA provide training, resources, and technical assistance to schools. LEA support implementation of school-based strategies through district level actions and decisions. Funding will be used for two main purposes: conduct school-based surveillance of health risk behaviors and school health policies and practices. Recipients will improve the health of middle school and high school students by collecting and using quality surveillance data. The funding to school districts will establish and strengthen systematic procedures to collect Youth Risk Behavior Survey (YRBS) and School Health Profiles (Profiles) data. School districts will report results to help support development of policies and practices to reduce priority health-risk behaviors among youth. build the capacity of districts and schools to contribute to reducing HIV infection, other STD, and related risk behaviors among adolescents, as well as reducing disparities in HIV infection and other STD among specific adolescent sub-populations. Recipients will improve the health of middle school and high school students by: collecting and using quality surveillance data; strengthening HIV/STD instruction and delivery; strengthening access to/use of key health services; and establishing / maintaining safe and supportive environments. Schools play an important role in HIV/STD prevention. Schools can influence students’ risk for HIV and other STD infection, and related negative health outcomes, through parental engagement, health education, connection to physical and mental health services, and fostering connectedness among youth and trusted adults. This funding opportunity supports implementation of activities at multiple levels of the education system to achieve health goals. Funded recipients will be the legal entity who has responsibility for public school district governance in that applicant’s jurisdiction.